Know Your Heart And Learning

Liver is the largest gland in the body, located in the abdominal cavity to the right, exactly below the diaphragm. Based on its function, the liver was also included as a means of excretion. This is because the liver helps the kidney function by breaking several compounds that are toxic and produce ammonia, urea, and uric acid by utilizing the nitrogen from amino acids. Solving process toxic compounds by the liver is the detoxification process.
Liver lobe is formed from cells and cell parenkimal non-parenkimal. Tues parenkimal called hepatocytes in the liver, occupying about 80% liver volume and perform the main functions of the liver. 40% of cells contained in the lobe of the liver sinusoidal lumen lobes formed from the SEC and is occupied by three other cell types, such as Kupffer cells, Ito cells, lymphocytes intrahepatik such as pit cells. Tues non-parenkimal occupies about 6.5% volume of the liver and produces a variety of substances that control many functions of hepatocytes.
Filtration is one function that separates the lumen of the lobe sinusoidal hepatocyte surface of the blood, the SEC has a very large capacity of endocytosis with various ligands such as glycoproteins, immune complexes, transferrin and seruloplasmin. The SEC also functions as an antigen presenter cells that provide expression of MHC I and MHC II to T cells Secretion that occurs includes various sitokina, such as prostanoid and leukotriena eikosanoid, endothelin-1, nitric oxide and several ECM components.
Tues perisinusoidal Ito is on a network, a cell with many fatty vesicles in the cytoplasm that binds very strong SEC to provide a double layer on the lumen of sinusoidal lobes. When the heart is in normal condition, Ito cells store vitamin A in order to control the flexibility of the extracellular matrix formed with the SEC, which is also the flexibility of the lumen of sinusoids.
Tues Kupffer intrasinusoidal are on the network, is makrofaga endositik and phagocytic ability of staggering. Tues Kupffer interact daily with digestive tract originating materials that contain bacterial solution, and prevent the activation of these compounds the effects of toxin into the liver. Solution of high bacterial exposure, particularly exposure to LPS, Kupffer cells do make sitokina that trigger the secretion of various inflammatory processes and may cause injury to the liver. Secretion include reactive oxygen species, eikosanoid, nitric oxide, carbon monoxide, TNF-α, IL-10, as derived immune response in acute infection phase.
Tues pit is a large granular lymphocytes with, such as NK cells reside in the liver. Tues pit can induce instant death in tumor cells without relying on the expression of antigens on major histocompatibility complex. Pit cell activity can be enhanced by interferon-γ stimulation.