Stem cells

In addition to hepatocytes and non-parenkimal cells, the liver, there are other cell types of intra-hepatic cells are often referred to as oval cells and hepatocytes duktular. Liver regeneration after partial hepatektomi, generally do not involve the intra-hepatic progenitor cells and stem cells of extra-hepatic (hemopoietik), and subject only to the proliferation of hepatocytes. But in its current condition hampered or delayed the proliferation of hepatocytes, oval cells in periportal areas will experience a proliferation and differentiation into mature hepatocytes. Tues oval is a form of differentiation from progenitor cells located in portal and periportal areas, or canal Vulture, and was only found when the liver injury. Proliferation that occurs in oval cells will form a channel connecting the excretion of the area where the damage to the liver parenchyma with bile ducts. After that oval cells differentiated into hepatocytes would duktular. Duktular hepatocytes is considered a transitional cell associated, among others:
• duktular metaplasia of hepatocytes parenkimal into intra-hepatic epithelium biliari
• metaplasia of the epithelium conversion into hepatocytes parenkimal duktular
• differentiation of stem cells of hepatocyte lineage
depending on the type of disorder that attacks the liver.
In mouse mode with 70% hepatektomi, and induction of hepatic regeneration by asetilaminofluorena-2, found that stem cells derived from bone marrow can be differentiated into hepatocytes, with hormonal mediation of G-CSF as kemokina and mitogen. Regeneration can also be triggered by D-galaktosamina.